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FLASH GENE
Symbol TNS1 contributors: mct - updated : 13-04-2017
HGNC name tensin 1
HGNC id 11973
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a phosphatase tensin-type domain
  • a C2 tensin-type domain
  • a SRC homology 2 domain
  • C-terminal tandem SH2-PTB domain pairing
  • HOMOLOGY
    interspecies homolog to rattus Tns1 (89.3 pc)
    homolog to murine Tns1 (89.9 pc)
    Homologene
    FAMILY
  • subtilisin serine protease family
  • CATEGORY structural protein , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • cell-substrate junction
  • focal adhesion
  • basic FUNCTION
  • may be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton
  • required for the maintenance of normal renal function
  • thought to act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility
  • large intracellular proteins believed to link the extracellular matrix to the cytoskeleton via integrins
  • distinct differences in the cellular expression of TNS1, TENC1, and TNS3, suggesting that they may be able to function independently of each other in the kidney and the small intestine
  • is a focal adhesion molecule that links the actin cytoskeleton to integrins and forms signaling complexes through its multiple binding domains
  • is a key component of specialized cellular adhesions (fibrillar adhesions) that bind to extracellular fibronectin fibrils
  • plays an essential role in TGFB1-induced myofibroblast differentiation and myofibroblast-mediated formation of extracellular fibronectin and collagen matrix
  • CELLULAR PROCESS cell organization/biogenesis
    cell migration & motility
    PHYSIOLOGICAL PROCESS development
    text
  • cartilage development
  • PATHWAY
    metabolism
    signaling signal transduction
  • TNS1-DLC1-RhoA signaling axis is critical in regulating cellular functions that lead to angiogenesis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with phosphotyrosine-containing proteins
  • binding to actin filaments
  • interacting with STARD8
  • TNS1 enhances RHOA activity in a DLC1-dependent manner
  • cell & other
    REGULATION
    Other rapidly cleaved by calpain II
    tyrosine phosphorylated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    anti-metastatic therapies may benefit from restoring or preserving tensin expression in primary tumors
    ANIMAL & CELL MODELS
    tensin-null mice (Lo, 1997)