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FLASH GENE
Symbol ITPKC contributors: mct - updated : 09-02-2008
HGNC name inositol 1,4,5-trisphosphate 3-kinase C
HGNC id 14897
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a nuclear import activity residing in its N-terminal domain and a nuclear export activity sensitive to treatment with leptomycin B
  • conserved catalytic domain of 275AA ATP binding site
  • six potential protein kinase C phosphorylation sites
  • HOMOLOGY
    Homologene
    FAMILY inositol phosphokinase (IPK) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text nucleo-cytoplasmic shuttling
    basic FUNCTION
  • catalyzing the phosphorylation of Ins(1,4,5)P3 to Ins(1,3,4,5)P4, both of which are modulators of calcium homeostasis
  • acting as a negative regulator of T-cell activation through the Ca2+/NFAT signaling pathway
  • playing a potential role as direct INSP3 metabolizing enzyme and direct regulator of Ca2+ responses to extracellular signals
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by by calmodulin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Kawasaki disease
    Variant & Polymorphism SNP a functional SNP (itpkc-3) significantly associated with Kawasaki disease susceptibility and also with an increased risk of coronary artery lesions in children
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS