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FLASH GENE
Symbol CHRDL1 contributors: mct/npt/pgu - updated : 26-05-2015
HGNC name chordin-like 1
HGNC id 29861
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • signal peptide, cysteine rich repeat
  • Von Willebrand factor type C domain
  • four chrd domains
  • three CR domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Chrdl1
    homolog to rattus Ng1
    intraspecies paralog to CHRDL2
    Homologene
    FAMILY
  • chordin family
  • bone morphogenetic protein (BMP) superfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • determining and maintaining the regional specificity along the dorsal ventral (anteroposterior) axis of retina
  • may serve as an important BMP regulator for differentiating mesenchymal cells, especially during skeletogenesis, and for developing specific neurons
  • may function as a modulator of BMP signaling during embryonic development
  • plays a role in regulating angiogenesis
  • reduces BMP7 signaling in healthy renal proximal tubules, and the loss of this activity upon sloughing of injured epithelia promotes BMP7 signaling in repopulating, dedifferentiated epithelia
  • requirement for ventroptin during eye anterior segment development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
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