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FLASH GENE
Symbol TEX11 contributors: mct - updated : 30-09-2020
HGNC name testis expressed sequence 11
HGNC id 11733
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • TEX11, testis expressed gene 15 (TEX15), mutL homolog 1 (MLH1), and homolog 3 (MLH3), play critical roles in genome integrity, meiotic recombination, and gametogenesis
  • TEX11, involved in the initiation and maintenance of chromosome synapses in meiotic chromosomes, has been shown to be essential for meiosis and fertility in males
  • regular expression of TEX11, TEX12, TEX14 and TEX15 is essential for the early stages of spermatogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SHOC1 interacts with TEX11, another protein important for the formation of COs, connecting SHOC1 to chromosome axis and structure
  • SHOC1 forms discrete foci on chromosomes axes, and is required for the localization of TEX11 and another ZMM protein, MSH4, to form crossover-prone recombination intermediates
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGFX2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the germ cells may partially contribute to the spermatogenic defect observed in Klinefelter syndrome (KS) patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS