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FLASH GENE
Symbol NXF2 contributors: - updated : 20-04-2006
HGNC name nuclear RNA export factor 2
HGNC id 8072
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-domain required for interaction with KIF17
  • four leucine-rich repeat,RNP-type RNA6 -binding domain-(RBD)
  • a nuclear transport, factor 2 (NF2) like domain and ubiquitine-associated domain
  • a UBA-like domain
  • a RNA recognition motif (RRM) domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Nxf2
    homolog to zebrafish Dr.6607
    homolog to Drosophila sbr
    homolog to C.elegans nxf-1
    intraspecies homolog to NXF1
    Homologene
    FAMILY family of nuclear RNA export factor genes
    CATEGORY RNA associated , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nuclear envelope
    text associated with the nuclear envelope
    basic FUNCTION
  • involved in mRNA export from the nucleus to the cytoplasm
  • a nucleo-cytoplasmic mRNA transporter, playing additional roles in the cytoplasmic localization of mRNAs through interactions with cytoplasmic motor proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • mRNA-nucleus export
  • protein-nucleus import
  • PATHWAY
    metabolism
    signaling
    a component heterodimerized with NXT1 AND NXT2
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • NXT1
  • NXT2
  • E1B-AP5
  • the REF proteins
  • nucleoporins (Nup62, Nup153 and Nup214)
  • interacting with KIF17
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS