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FLASH GENE
Symbol STK31 contributors: mct - updated : 20-02-2019
HGNC name serine/threonine kinase 31
HGNC id 11407
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • TUDOR domain,
  • coiled coil domain
  • serine/threonine protein kinase (STK) catalytic domain
  • HOMOLOGY
    interspecies homolog to murine Stk31
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm,nuclear bodies
    intracellular,nucleus,chromatin/chromosome,centromere
    text
  • co-localizes with pericentrin in the centrosomal region throughout all phases of the cell cycle; also localizes to the centromeres, central spindle, and midbody
  • basic FUNCTION
  • is able to control the differentiation state of colon cancer cells, which critically depends on its STK domain
  • STK31 may be redundant with other TDRD proteins in germ cell development
  • STK31 gene of which the expression has been proven to be regulated by the methylation status of its promoter, is one of the novel cancer/testis (CT) genes and plays important roles in cancers
  • STK31 is a positive apoptosis regulator that inhibits tumorigenesis of colon cancer cells by inducing PDCD5-mediated apoptosis in response to genotoxic stress
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may be a novel cellular target gene for the HPV16 oncogeneE7
  • STK31 interacts with PDCD5, which maintains the stability of PDCD5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in patients with pancreatic carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serum FBLN1 and STK31 are biomarkers of colorectal cancer, having ability to noninvasively differentiate colorectal cancer from benign polyps
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    might act as a potential therapeutic target in human somatic cancers
    ANIMAL & CELL MODELS
  • mouse Stk31 could be a potential nuage-associated protein in the cytoplasm of mid-to-late spermatocytes and play pivotal roles related to fertilization