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FLASH GENE
Symbol TEX14 contributors: mct/npt - updated : 24-12-2016
HGNC name testis expressed 14
HGNC id 11737
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three ankyrin repeats
  • a protein kinase domain
  • and a leucine zipper dimerization motif (Wu 2003)
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • predicted to be localized to the nucleus (Wu 2003)
  • localizes to germ cell intercellular bridges (Greenbaum 2006)
  • basic FUNCTION
  • required for intercellular bridges in vertebrate germ cells and these bridges are essential for spermatogenesis and fertility (Greenbaum 2006)
  • may play a key role in regulating gene expression or modulating nuclear events during mammalian spermatogenesis (Wu 2003)
  • essential component of male and female embryonic intercellular bridges (Greenbaum 2009)
  • TEX14 and intercellular bridges have an essential role in postnatal spermatogenesis, they are not required in the embryo (Greenbaum 2009)
  • is an important mediator of kinetochore structure and function and the fidelity of chromosome separation
  • component of intercellular bridges in germ cells, that is required for spermatogenesis and fertility
  • regular expression of TEX11, TEX12, TEX14 and TEX15 is essential for the early stages of spermatogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CEP55 to block cell abscission (Iwamori 2010)
  • recruited to kinetochores (KTs) by PLK1 in a CDK1-dependent manner during early mitosis
  • TEX14 competitively binds to CEP55-EABR to prevent the recruitment of PDCD6IP, which is a component of the ESCRT machinery with the AxGPPx3Y motif
  • DAZL determines primordial follicle formation through the translational regulation of TEX14
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF23
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    spermatogenesis in Tex14(-/-) mice progresses through the transit amplification of diploid spermatogonia and the expression of early meiotic markers but halts before the completion of the first meiotic division (Greenbaum 2006)