basic FUNCTION
| acting as an adaptor in targeting mRNAs associated with phosphorylated UPF1 for degradation |
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required for telomere DNA maintenance (de Zwaan 2009) |
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upregulates the telomerase DNA extension activity independent of DNA interactions (de Zwaan 2009) |
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SMG5-SMG7 and SMG6 exhibit different and non-overlapping modes of UPF1 recognition, thus pointing at distinguished roles in integrating the complex NMD interaction network |
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degradation of NMD target mRNAs involves both exonucleolytic and endonucleolytic pathways in mammalian cells, and the former pathway has been reported to require a complex of SMG5-SMG7 |
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14-3-3-related protein that SMG7 plays critical roles in regulation of DNA damage response and nonsense-mediated mRNA decay (NMD) |
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likely function using additional distinct regulatory mechanisms besides phosphoserine-mediated protein interactions |
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loss of the first SMG5-SMG7-dependent pathway also inactivates the second SMG6-dependent branch, indicating an unexpected functional connection between the final NMD steps |