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FLASH GENE
Symbol SMG7 contributors: mct - updated : 23-01-2024
HGNC name Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
HGNC id 16792
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two TPR repeats
  • 14-3-3-like domain
  • HOMOLOGY
    interspecies ortholog to murine Smg7
    Homologene
    FAMILY
    CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • acting as an adaptor in targeting mRNAs associated with phosphorylated UPF1 for degradation
  • required for telomere DNA maintenance (de Zwaan 2009)
  • upregulates the telomerase DNA extension activity independent of DNA interactions (de Zwaan 2009)
  • SMG5-SMG7 and SMG6 exhibit different and non-overlapping modes of UPF1 recognition, thus pointing at distinguished roles in integrating the complex NMD interaction network
  • degradation of NMD target mRNAs involves both exonucleolytic and endonucleolytic pathways in mammalian cells, and the former pathway has been reported to require a complex of SMG5-SMG7
  • 14-3-3-related protein that SMG7 plays critical roles in regulation of DNA damage response and nonsense-mediated mRNA decay (NMD)
  • likely function using additional distinct regulatory mechanisms besides phosphoserine-mediated protein interactions
  • loss of the first SMG5-SMG7-dependent pathway also inactivates the second SMG6-dependent branch, indicating an unexpected functional connection between the final NMD steps
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA associates with the DNA during telomerase-mediated DNA lengthening (de Zwaan 2009)
    RNA
    small molecule
    protein
  • interaction with CDC13, critical for modulating telomerase DNA extension activity (de Zwaan 2009)
  • SMG5-SMG7 interaction is conserved and is crucial for efficient NMD in human cells
  • mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors SMG1, SMG7, UPF1 to destabilize the mRNA of CDKN1A
  • SMG7 is an indispensable signaling component in the ATR-CEHK1 pathway during genotoxic stress response
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS