Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol EDEM3 contributors: mct - updated : 07-09-2021
HGNC name ER degradation enhancer, mannosidase alpha-like 3
HGNC id 16787
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • Class I alpha-mannosidases (glycosyl hydrolase family 47) in its N-terminal domain
  • four consecutive modules defined as GH47, intermediate (IMD), protease-associated (PA), and intrinsically disordered (IDD) domain (
  • a protease-associated motif in its C-terminal region
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Edem3
    Homologene
    FAMILY glycosyl hydrolase 47 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • alpha1,2-mannosidases activity
  • enhancing endoplasmic reticulum-associated degradation (ERAD)
  • is a regulator of blood triglyceride (TG)
  • EDEM3 provides a unique ERAD timing to misfolded glycoproteins, not only by its mannose trimming activity, but also by the positive and negative feedback modulated by the protease-associated and intrinsically disordered domain, respectively
  • involved in the endoplasmic reticulum-associated degradation pathway, responsible for the recognition of misfolded proteins that will be targeted and translocated to the cytosol and degraded by the proteasome
  • participates in mannose trimming from total glycoproteins
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TXNDC5, an ER-resident oxidoreductase, associates stably with EDEM3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2V
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS