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FLASH GENE
Symbol SUPT6H contributors: mct/npt - updated : 22-02-2017
HGNC name suppressor of Ty 6 homolog (S. cerevisiae)
HGNC id 11470
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • SH2 domain and a leucine zipper
  • HOMOLOGY
    interspecies homolog to yeast spt6 (suppressor of Ty)
    Homologene
    FAMILY
  • emb-5 transcription initiation factor STP6 family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • putative chromatin structure regulator
  • may be a mediator of differentiation and development through the establishment and/or maintenance of
  • chromatin structure
  • promotes transcription elongation at many genes and functions as a histone H3 chaperone to alter chromatin structure during transcription (Yoh 2007)
  • significantly precedes Swi/Snf occupancy at the promoter and in absence of SSPN recruitment, Swi/Snf is constitutively found at the promoter (Zhang 2008)
  • participating in the regulation of transcription by RNA polymerase II (RNAPII)
  • is involved in differential regulation of class switch recombination (CSR) and somatic hypermutation (SHM) by AICDA
  • cellular protein SUPT6H is required for efficient replication of human cytomegalovirus
  • is a unique histone chaperone capable of regulating the histone epigenetic state of both activation-induced cytidine deaminase (AID) targets and the AID locus
  • regulates class-switch recombination (CSR) through H3K4me3 modification of the target chromatin
  • regulates transcription and DNA breakage
  • is a histone chaperone that links transcriptional elongation to changes in chromatin structure
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • IWS1 connects two distinct C-terminal domain-binding proteins, SUPT6H and SETD2, in a megacomplex that affects mRNA export as well as the histone modification state of active genes (Yoh 2008)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with SSPN (recruited via interaction with RNAPII, and SSPN is necessary for SUPT6H recruitment) (Zhang 2008)
  • binds Ser2-phosphorylated (Ser2P) RNA polymerase II (RNAPII) through a primitive SH2 domain, which recognizes phosphoserine rather than phosphotyrosine residues (Yoh 2007)
  • IWS1 is SUPT6H-interacting protein (Yoh 2007)
  • KDM6B and KDM7A play a role in localizing elongation factors SUPT6H and SUPT16H to the target genes
  • SUPT6H regulates both class-switch recombination (CSR) and somatic hypermutation through H3K4me3 marks on AICDA target loci
  • SUPT6H is a unique histone chaperone capable of regulating the histone epigenetic state of both AICDA targets and the AICDA locus
  • through cooperation with POLR2A and KDM6A, SUPT6H orchestrates removal of H3K27me3, thus controlling developmental gene expression and cell differentiation
  • is required for estrogen-regulated transcription and the maintenance of chromatin structure in breast cancer cells, possibly in part through interaction with RNF40
  • is a new epigenetic regulator of ESR1 activity and cellular differentiation
  • SUPT6H recruitment is abrogated in cells lacking the histone methyltransferase NSD2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS