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FLASH GENE
Symbol FBXL2 contributors: mct - updated : 27-03-2013
HGNC name F-box and leucine-rich repeat protein 2
HGNC id 13598
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 40 AA F box motif
  • a F box domain
  • a CAAX motif (CVIL) (PMID;
  • twelve,leucine-rich repeats (LRR) at the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • F box protein family
  • SCF (Skip-Cullin1-F-box protein) E3 ligase family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • phosphorylation dependent ubiquination
  • substrate recognition subunit of SCF ubiquitin protein ligase complex
  • geranylgeranylated cellular protein required for hepatitis C virus RNA replication (PMID;
  • impairs cell proliferation by mediating cyclin D3 polyubiquitination and degradation
  • implicated as an indispensible regulator of mitosis that serves as a tumor suppressor (
  • role for SCF (FBXL2) in regulating the fidelity of cellular division
  • ubiquitinates and destabilizes cyclin D2 protein leading to G(0) phase arrest and apoptosis in leukemic and B-lymphoblastoid cell lines
  • is a novel and dual regulator of APP metabolism through FBXL2-dependent ubiquitination of APP
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the four subunits of the E3 ubiquitin protein ligase complex :(SCF) with SKP1, CUL1, RBX1, F-box protein bringing ubiquitin conjugating enzymes to substrates recruited by F-box
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • various target proteins
  • uniquely recognizes a canonical calmodulin (CALM1)-binding motif within CCND3 to facilitate its polyubiquitination
  • regulates amyloid precursor protein (APP) metabolism through APP ubiquitination
  • FBXO3 potently stimulates cytokine secretion from human inflammatory cells by mediating the degradation of the TRAF inhibitory protein, FBXL2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    antiproliferative effect of FBXL2 in lymphoproliferative malignancies
    ANIMAL & CELL MODELS