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FLASH GENE
Symbol DPP8 contributors: npt/mct - updated : 07-05-2019
HGNC name dipeptidyl-peptidase 8
HGNC id 16490
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminus having functional importance of the C-terminal loop to the whole family of prolyl dipeptidases
  • mono polymer monomer , dimer
    HOMOLOGY
    intraspecies homolog to DPP4
    homolog to FAP
    Homologene
    FAMILY
  • peptidase S9B family
  • DPPIV subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • capable of cleaving the peptide bond after a penultimate proline residue
  • T cell activation and immune function
  • involved in cleavage of the N-terminal two residues of
  • CXCL10, CXCL11 and CXCL12
  • influence cell-extracellular matrix interactions, and thus may regulate tissue remodeling
  • physiological role of DPP8, DPP9 in the male reproductive system
  • biological roles for DPP8 and DPP9 in lymphocyte activation and apoptosis and in hepatocytes during liver disease pathogenesis
  • DPP8 and DPP9 are involved in multiple cellular pathways including antigen maturation, cellular homeostasis, energy metabolism, and cell viability
  • importance of DPP8 and DPP9 on adipogenesis
  • DPP8 and DPP9 are intracellular N-terminal dipeptidyl peptidases (preferentially postproline) associated with pathophysiological roles in immune response and cancer biology
  • regulates cell proliferation, apoptosis, migration and invasion during cancer progression
  • promotes the progression of cervical cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component predominantly dimeric
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DPP9 and DPP8, associate with HRas, a key signal molecule of the EGF receptor signaling pathway, suggesting an important signaling role of DPP9 in the regulation of survival and proliferation pathways
  • UBA2 interacts with both SUMO1 and SUMO2, both DPP8 and DPP9 showed a strong preference toward SUMO1 binding
  • cytosolic serine dipeptidyl peptidases DPP8 and DPP9 suppress inflammasome activation upstream of NLRP1 and CARD8 in human keratinocytes and peripheral blood mononuclear cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    exhibited impaired cell migration on collagen I and impaired wound healing on collagen I and fibronectin
    tumoral     --over  
    in cervical cancer tissues and cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveuterus
    silencing the expression of DPP8 not only suppressed the proliferation, migration and invasion of the cervical cancer cells, but also promoted cervical cancer cell apoptosis
    ANIMAL & CELL MODELS