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FLASH GENE
Symbol PIK3R3 contributors: mct - updated : 05-12-2018
HGNC name phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
HGNC id 8981
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal YXXM motif, two SH2 domains, binding site
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine P55pik
    Homologene
    FAMILY
  • PI3K p85 subunit family
    • CATEGORY signaling , receptor membrane
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • interacting with the IGFIR and INSR and may be involved in PI 3-kinase activation by these receptors
  • 1-phosphatidylinositol-3-kinase activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IGF1R or INSR
  • ADTRP positively regulates PIK3R3 expression, which leads to activation of AKT1 and up-regulation of MIA3, thereby regulating endothelial cell functions directly relevant to atherosclerosis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS