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FLASH GENE
Symbol MAP4K3 contributors: mct/npt - updated : 29-10-2009
HGNC name mitogen-activated protein kinase kinase kinase kinase 3
HGNC id 6865
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal catalytic domain (tyrosine kinase)
  • two PEST motifs
  • three proline-rich region
  • C-terminal PEST domain that might play a role in the modulation of MAP4K3 stability through regulation by the ubiquitin-proteasome system (Lam 2009)
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • STE20 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • serine/threonine protein kinase activity
  • activating the C-JUN-N-terminal kinase (JNK) signaling pathway
  • required for maximal RPS6/EIF4EBP1 phosphorylation and regulates cell growth (Findlay 2007)
  • can act as a general mediator of DNA damage-induced cell death (Lam 2009)
  • pro-apoptotic kinase that induces mitochondria-dependent apoptosis via BAX activation (Lam 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • contributes to the activation of both the JNK and mTOR signaling pathways (Lam 2009)
  • modulates the activity of the BH3 proteins BBC3, BAD, and BCL2L11 at the posttranscriptional level (Lam 2009)
  • cell & other
    REGULATION
    activated by phosphorylation
    exposure to UV radiation or to tumor necrosis factor-alpha
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    resulted in significant resistance to DNA damage-induced cell death (Lam 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS