basic FUNCTION
| acting as a transcriptional coactivator for NOTCH-signaling |
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amplifying NOTCH-induced transcription of HES1 |
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enhancing phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8 |
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inducing phosphorylation and localization of CREBBP to nuclear foci |
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playing a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions |
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binding to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription |
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increasing the half-life of p53 protein |
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enhancing the TP53 phosphorylation/acetylation upon DNA damage of cells |
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specific coactivator for the Notch pathway, as a coactivator for beta-catenin and participates in the Wnt signaling by modulating the beta-catenin/TCF activity |
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in colonic carcinoma cells having a role in cell death by affecting beta-catenin-induced expression of cyclin D1 and c-Myc |
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plays an important role in Notch-regulated transcription, by direct interactions with Notch, EP300 and histone |
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novel modulator for NF-KB signaling and regulates cellular survival |
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engagement of Mastermind (Mam) is essential for Notch signaling, and MAML1, MAML2, MAML3 have distinct roles |
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MAML1 and RBPJ, which are components of the Notch transcription complex, enhance Notch acetylation and we suggest that MAML1 increases Notch acetylation by potentiating EP300 autoacetylation |
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may be a component of the transcriptional networks which regulate EGR1 target genes during nephrogenesis and could also have implications for the development of renal cell carcinoma |
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enhances the transcriptional activity of RUNX2, a transcription factor essential for osteoblastic differentiation and chondrocyte proliferation and maturation |
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might be a key regulator of Notch stability in the nucleus by interacting with either EP300, which leads to increased Notch receptor stability, or the recruitment of CDK8 for Notch degradation |