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FLASH GENE
Symbol SLC14A2 contributors: mct/npt - updated : 20/12/2008
HGNC name solute carrier family 14 (urea transporter), member 2
HGNC id 10919
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nine transmembranes domains
  • HOMOLOGY
    Homologene
    FAMILY
  • urea transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text descending thin limbs of Henle foop and descending vasa recta
    basic FUNCTION
  • participating in urinary recycling processes which minimize urea escape from the inner medulla
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS excretion , facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by changes in dietary protein content and hydration state, independently of SLC14A1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to variation in blood pressure
    Variant & Polymorphism SNP Ile 227, Ala357 associated with low pressure
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS