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FLASH GENE
Symbol XPNPEP1 contributors: mct - updated : 26/09/2008
HGNC name X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
HGNC id 12822
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a proton shuttle and five divalent metal ligand sites
  • a C terminal hexahistidine tag, catalytic domain coordinating two metal ions and sharing a similar fold with other prolyl aminopeptidases
  • mono polymer dimer
    HOMOLOGY
    interspecies homolog to E.coli methionine aminopeptidase
    Homologene
    FAMILY
  • pita-bread-fold protein family
  • metallopeptidase family M24
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text cytosolic
    basic FUNCTION
  • catalyze the removal of a penultimate prolyl residue from the N termini of peptides
  • playing a role in the maturation and degradation of peptide hormone, neuropeptide and tachykinin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • manganese Mn2+
  • cobalt Co2+
  • protein
  • can degrade bradykinin, a blood pressure-regulating peptide
  • cell & other
    REGULATION
    inhibited by by the specific peptide inhibitor apstatin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS