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FLASH GENE
Symbol TOMM22 contributors: mct - updated : 05-02-2018
HGNC name translocase of outer mitochondrial membrane 22 homolog (yeast)
HGNC id 18002
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal negatively charged region
  • a putative transmembrane region
  • a C terminal intermembrane space region with little negative charge
  • a large cytosolic domain, which has been shown to be sensitive to proteolysis, that appears to function as a receptor in cooperation with TOMM20
  • HOMOLOGY
    interspecies ortholog to murine Tomm22
    ortholog to rattus tom22
    Homologene
    FAMILY TOM22 family
    CATEGORY chaperone/stress , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    text
  • distributions of clusters of TOMM20 and of TOMM22 follow an inner-cellular gradient from the perinuclear to the peripheral mitochondria
  • basic FUNCTION
  • mitochondrial import receptor having chaperone-like activity
  • import receptor and organizer of the TOM complex involved in protein translocation into mitochondria and has a dual role, as it is a component of the general insertion pore together with the pore-forming protein TOMM40 and, as such, is involved in protein translocation across the mitochondrial outer membrane
  • apparently involved in the same step or sequential steps along the same pathway of targeting signal recognition in import as TOMM20, but may recognize opposite sides of the same presequence in the same step (TOMM20 recognizing the hydrophobic surface and TOMM22 the hydrophilic surface)
  • is a critical regulator of steroidogenesis, and thus, it is essential for mammalian survival
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with several other proteins to import cytosolic preproteins into the mitochondrion
  • core component of the mitochondria outer membrane protein translocation pore
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with TOMM20 and TOMM40
  • mitochondrial receptor for the proapoptotic protein BAX
  • import receptor for proteins lacking conventional mitochondrial presequences
  • interaction with the cytosolic domain of TOMM22 helps BAX to acquire a conformation able to interact with the outer mitochondrial membrane
  • CSNK2A1, CSNK2A2-dependent phosphorylation of TOMM22 is a critical switch for mitophagy and reveal CSNK2A-dependent physiological implications on metabolism, muscle integrity and behavior
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS