basic FUNCTION
| playing in important roles in spermatogenesis, especially in the formation and maintenance of the acrosome |
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may function normally to suppress cell growth and/or enhance maturation |
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centromeric form may be the base to anchor the MIS12 core complex that is enriched with coiled coils and extends to outer ZWINT during mitosis |
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may be the center of the network for generating kinetochore-based checkpoint signaling |
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CASC5 and CENPK, a subunit of a constitutively centromere-associated complex, coordinately direct NDC80 complex localization and kinetochore assembly |
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mixed-lineage leukemia (MLL) fusion partner and a kinetochore component |
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microtubule binding by CASC5 functions in checkpoint silencing by sensing microtubules attached to kinetochores and relaying their presence to eliminate generation of the checkpoint signal |