Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CLK4 contributors: - updated : 29-08-2006
HGNC name CDC-like kinase 4
HGNC id 13659
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to rattus Clk4 (97.5pc)
ortholog to murine Clk4 (97.1pc)
ortholog to chicken CLK4 (83.6pc)
Homologene
FAMILY
  • CDC2/CDC28-like kinase family
  • Ser/Thr protein kinase family
  • Lammer subfamily
  • CATEGORY enzyme , receptor membrane
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • phosphorylating serine- and arginine-rich proteins of the spliceosomal complex
  • may be a constituent of a network of regulatory mechanisms that enable serine- and arginine-rich proteins to control RNA splicing
  • required for the regulation of alternative splicing of MAPT/TAU
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with and inducing the nuclear redistribution of SR proteins SFRS* (see symbols)
  • UBL5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS