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FLASH GENE
Symbol KIN contributors: mct/npt - updated : 06/11/2008
HGNC name KIN, antigenic determinant of recA protein homolog (mouse)
HGNC id 6327
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a zinc finger motif (residues 28-50) within a 30-kDa N-terminal region conserved from yeast to human
  • a 39 AA domain with significant homology ro recA
  • WH module presenting an additional and highly conserved 3(10)-helix, involved in protein-protein interaction through its conserved surface centered on the 3(10)-helix
  • a 15-kDa C-terminal tandem of SH3-like subdomains, crucial for the anti-proliferation effect
  • secondary structure three-alpha-helix bundle packed against a three-stranded beta-sheet
    HOMOLOGY
    interspecies homolog to murine Kin17
    Homologene
    FAMILY
  • winged helix (WH) family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nuclear envelope,matrix attachement regions
    basic FUNCTION
  • UVC-responsive gene involved inDNA replication (in presence of functional global genome repair)
  • DNA- and RNA-binding protein that plays an important role in nuclear metabolism and in particular in the general response to genotoxics
  • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    induced by UVC irradiation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    following exposure to ionizing radiations and UV light, depending on the integrity of the global genome repair machinery
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS