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FLASH GENE
Symbol KDM4C contributors: mct - updated : 02-06-2010
HGNC name lysine (K)-specific demethylase 4C
HGNC id 17071
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a JmjC domain
  • a JmjN domain
  • conserved dual PHD and Tudor domains in addition to their JmjC domains
  • a catalytic Jumonji C 2 domain
  • HOMOLOGY
    interspecies ortholog to Kdm4c, Mus musculus
    ortholog to Kdm4c, Rattus norvegicus
    ortholog to KDM4C, Pan troglodytes
    Homologene
    FAMILY
  • Jumonji domain 2 (JMJD2) family
  • KDM4 histone demethylase subfamily
  • CATEGORY enzyme , transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • leads to tumor formation
  • demethylate histone lysine and arginine residues in an oxidative reaction that requires Fe(II) and alpha-ketoglutarate as cofactors
  • and promotes both transcriptional activation of androgen receptor target genes and proliferation of prostate cancer cells
  • playing an important role in the development and/or progression of various type of cancers
  • acting as a histone trimethyl demethylase
  • histone demethylase implicated in the epigenetic reprogramming during the early embryogenesis
  • acts as a positive regulator for NANOG, which encodes for a key transcription factor for self-renewal in embryonic stem cells
  • generates different methylated states at the same lysine residue provides a mechanism for fine-tuning histone methylation
  • histone demethylase with a Jumonji C domain that catalyzes lysine (K) demethylation of histones, specifically histone H3 at lysine 9 (H3K9) and lysine 36 (H3K36)
  • involved in maintaining gene expression programs that are important for self-renewal and differentiation in embryonic stem (ES) cells
  • atalytic Jumonji C 2 domain catalyzes lysine (K) demethylation of histones
  • KDM4A, KDM4B, KDM4C, catalyze demethylation of tri- and di-methylated forms of both histone H3 lysine 9 (H3K9me3/me2) and lysine 36 (H3K36me3/me2)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • androgen receptor (AR)
  • NOTCH1 is a novel target gene of GASC1
  • target of OCT4, as well as a key regulator of NANOG, (alteration of GASC1 could enhance and/or disrupt the autoregulatory circuit of the stem cell transcription factors in human cancer cells)
  • Mdm2 oncogene is upregulated by Jmjd2c through the changes of histone H3 methylation on the promoter
  • cell & other
    REGULATION
    Other positively regulated by the embryonic stem cell transcription factor POU5F1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in development or progression of esophageal squamous cell carcinoma
    tumoral   amplification    
    in esophageal cancer cell lines
    tumoral   amplification    
    in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene for anti-cancer therapy
    Marker
    Therapy target targeted inhibition of GASC1 histone demethylase in cancer could provide potential new avenues for therapeutic development
    ANIMAL & CELL MODELS