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FLASH GENE
Symbol WRAP73 contributors: mct - updated : 04-01-2017
HGNC name WD repeat containing, antisense to TP73
HGNC id 12759
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two WD repeats
  • HOMOLOGY
    intraspecies homolog to HPRP4P
    Homologene
    FAMILY
  • WD repeat gene family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • inhibitor of endochondral ossification (role in regulation of ectopic ossification)
  • the conserved WRAP73-SSX2IP complex plays a critical role in controlling proper spindle length and orientation
  • satellite and centriolar component
  • WRAP73 and CEP135 have strongly overlapping functions in ciliogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • WRAP73 formed a complex and partially colocalised with SSX2IP
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WRAP73 interacts with the satellite proteins SSX2IP and PCM1 as well as the centriolar proximal end component CEP135
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS