basic FUNCTION
| involved in constitutive heterochromatin maintenance, actively participates in hormone-dependent transcriptional regulation affecting GR (glucocorticoid receptor) target gene expression in a promoter- and cell type-specific manner (Chinenov 2008) |
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KMT5B, KMT5C differ substantially in their localization and activity |
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its activity is required for the fidelity of chromosome distribution during meiosis in the mammalian oocyte |
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may be required for normal chromosome behaviour and that it is crucial for proper meiotic progression in mammalian oocytes |
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novel role of FRG1 as epigenetic regulator of muscle differentiation, indicating that SUV420H1 has a gene-specific function in myogenesis |
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KMT5B, KMT5C are two highly homologous enzymes that methylate lysine 20 of histone H4 (H4K20), a mark that has been implicated in transcriptional regulation |
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KMT5B is a H4K20 dimethyltransferase, that controls Skeletal muscle stem cells (MuSCs) quiescence by promoting formation of facultative heterochromatin (fHC) |
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actively regulates MuSC quiescence via fHC formation and control of the MYOD1 locus, thereby guarding and preserving the stem cell pool over a lifetime |
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KMT5B-mediated H4K20 tri-methylation is a critical determinant in the selection of active replication initiation sites in heterochromatin regions of mammalian genomes |