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FLASH GENE
Symbol TAS2R8 contributors: SGE/npt - updated : 11-06-2010
HGNC name taste receptor, type 2, member 8
HGNC id 14915
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • an extracellular lignand binding domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to a bitter cluster on murine chromosome 6
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • taste receptor family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • taste receptor cells of the tongue and palate epithelia
  • receptor that may play a role in the perception of bitterness and is gustducin-linked
  • may play a role in sensing the chemical composition of the gastro intestinal content
  • may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction , sensory transduction/taste
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS