Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DVL1 contributors: mct/pgu - updated : 16-04-2015
HGNC name dishevelled, dsh homolog 1 (Drosophila)
HGNC id 3084
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal DSH/DIX motif
  • one DEP domain
  • a Dlg, Discs-large suppressor tumor protein (DHR/GLGZ/PDZ) motif
  • C-terminal region (DVL1(DEP+)) interacts with APC , C terminus of DVL1 contains a number of proline-rich clusters
  • conjugated PhosphoP
    mono polymer heteromer , oligo
    HOMOLOGY
    interspecies homolog to Drosophila dishevelled segment polarity gene 1
    homolog to murine Dvl1 (94.9pc)
    homolog to C.elegans t05c12.6a
    homolog to rattus Dvl1 (95.1pc)
    intraspecies homolog to DVL3
    Homologene
    FAMILY
  • DSH family
  • CATEGORY regulatory , transcription factor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • activated in WNT signal transduction
  • putatively involved in neural and heart development
  • regulates cell proliferation, acting as a transducer molecule for developmental processes including segmentation and neuroblast specification
  • is required for LRP6 phosphorylation and aggregation after WNT treatment
  • involved in axon differentiation mediated by the PAR3-PAR6-aPKC complex
  • may play a role in the signal transduction pathway mediated by multiple Wnt genes
  • may contribute to the progression of NSCLCs
  • may be related to prostate cancer progression through the Wnt/beta-catenin pathway
  • inducing phosphorylation of MARK2 and thus regulating its membrane localization
  • DVL1, DVL2, DVL3 are core components in the correct routing and transmission of canonical and non-canonical Wnt signals, most likely by acting in large multiprotein complexes
  • with APC mediate a WNT5A-FZD2 signal to focal adhesions to regulate cell-substrate adhesions and migration
  • is a key regulator of both the canonical Wnt and the planar cell polarity (PCP) pathway
  • important determinants of Olfactory sensory neurons (OSNs) cell differentiation and axon extension
  • cytoplasmic protein which plays pivotal roles in the embryonic development
  • association of DVL1 and DVL3 with Hirschsprung disease (HSCR), it may play an important role in the pathogenesis of HSCR
  • may be an underlying participant of oxidative stress induced by selenium deficiency
  • is a central mediator of Wnt signal transduction
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    WNT7A-DVL1 signaling is required for spine morphogenesis and glutamatergic transmission in the hippocampus
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with myristoilated NKD2 at the plasma membrane, this interaction leading to their mutual ubiquitin-mediated proteasomal degradation
  • interacting with CXXC4, NXN, BRD7, INVS, VANGL1, VANGL2, CCDC88C/DAPLE, ARRB1
  • interacting with PI4K2A and forming a ternary complex with PIP5KI upon WNT3A stimulation
  • interacting with SMAD1 and thus coupling WNT and BMP signaling pathways
  • bound to APC directly and this complex played a role in the WNT5A-dependent formation of cell-substrate adhesions and polarized cell migration
  • VANGL2 promotes Wnt/planar cell polarity-like signaling by antagonizing DVL1-mediated feedback inhibition in growth cone guidance
  • required for WNT7A function
  • NEDD4 mediates the ubiquitylation and degradation of the adapter protein dishevelled-1 (DVL1), the expression of which negatively regulates cell-cell contact
  • ITCH is a DVL1-binding protein (ITCH ubiquitinates the phosphorylated form of DVL1 and promotes its degradation via the proteasome pathway, thereby inhibiting canonical Wnt signaling)
  • regulates precoupling of heterotrimeric G proteins to FZD6
  • DVL1 is a dual function adaptor to recruit negative regulators ZNRF3/RNF43 to Wnt receptors to ensure proper control of pathway activity
  • cell & other
    REGULATION
    Other
  • interaction with INVS is required for ubiquitination
  • ASSOCIATED DISORDERS
    corresponding disease(s) DEL1P36 , RBNSOS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    expressed in non-small cell lung cancer, positive expression correlated with pTNM stages and significantly higher in nodal metastases than in primary growths
    tumoral     --over  
    overexpressed in prostate cancer, expression level increasing with worsening histological grade
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate gene for neuroblastomatous transformation
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
    DVL1 small murine