protein
| activates transcription of the human TGF-beta 2 gene |
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activating transcription factor 2, ATF2 |
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retinoblastoma binding protein 4, RBBP4 and etinoblastoma binding protein 7, RBBP7 |
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nuclear matrix protein p84 |
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zinc finger protein RIZ |
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retinoblastoma-binding protein RBQ3 |
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Pur alpha, PURA |
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nuclear tyrosine kinase Rak |
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heat shock 70 kDa protein 1, Hsp70 |
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TATA-binding protein-associated factor TAFII250 |
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c-Myc protein, Myc |
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BRM/SWI2-related gene 1, BRG1 |
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lamin A, LMNA |
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serine/threonine protein kinase PITALRE |
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myogenic differentiation 1, MYOD1 |
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protein phosphatase 1, catalytic subunit, alpha isozyme, PPP1CA |
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cellular transcription factor PU.1 |
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E74-like factor 1 (ets domain transcription factor), ELF1 |
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nuclear factor of interleukin 6, NF-IL6 |
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E2F-1, E2F-2, and E2F-3 |
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heat shock protein 75 kDa, HSP75 |
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protein activator of the interferon-induced protein kinase, PACT |
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BCR-ABL |
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TFIIIB and TFIIIC2 |
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HMG-box transcription factor 1, HBP1 |
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TAF(II)250/TFIID |
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Trip230 |
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human cytomegalovirus major immediate-early 86-kDa protein, IE2 86 |
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DNA polymerase alpha, POLA |
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promyelocytic leukemia gene product, PML |
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minichromosome maintenance complex component 7, MCM7 |
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androgen receptor, AR |
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B5T overexpressed gene protein, Bog |
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aryl hydrocarbon receptor, AHR |
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retinoblastoma binding protein 8, RBBP8 |
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v-raf-1 murine leukemia viral oncogene homolog 1, RAF1 |
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cyclin A1, CCNA1 |
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c-Jun |
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paired box 5, PAX5 |
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paired box 6, PAX6 |
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Prohibitin, PHB |
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opoisomerase IIalpha |
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bright and dead ringer protein, BDP |
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p21 cyclin-dependent kinase, P21 |
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BRCA1 protein complexes with the hypophosphorylated form of pRb |
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Gankyrin |
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RB-associated KRAB protein, RBaK |
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rb-binding protein Che-1, CHE1 |
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p120E4F |
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insulin |
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RBP95 |
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UBF |
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E1A-like inhibitor of differentiation 1, EID-1 |
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represses RNA polymerase III transcription |
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SNAPc 43 kDa subunit, SNAP43 and SNAPc 50 kDa subunit, SNAP50 |
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aryl hydrocarbon receptor, AhR |
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ErbB-3 binding protein 1, EBP1 |
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SUV39H1 and HP1 |
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FERTILIZATION INDEPENDENT ENDOSPERM, FIE |
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activating transcription factor 2, ATF2 |
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de-ubiquitinating enzyme Unp |
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PKC beta 2 |
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DNA (cytosine-5-)-methyltransferase 1, DNMT1 |
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cdk9/cyclinT2 complex |
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paired box 2, PAX2 |
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cyclophilin A, CYPA |
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MORF-related gene on chromosome 15, MRG15 and protein associated with MRG of 14 kDa, PAM14 |
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Ski interacting protein, Skip |
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LAP2alpha, lamins A and C |
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peroxisome proliferator-activated receptor gamma, PPARgamma and Histone deacetylase 3, HDAC3 |
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proline, glutamate and leucine rich protein 1, PELP1 |
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Receptor of activated protein kinase C 1, RACK1 |
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BCL2-associated athanogene, BAG1 |
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CCAAT displacement protein, CDP |
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serpin plasminogen activator inhibitor 2, SERPINB2 |
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CCAAT enhancer binding protein epsilon, C/EBPepsilon |
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Activating signal cointegrator-2, ASC2 |
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with the N terminus of S-phase kinase-associated protein 2 (p45), SKP2 |
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lin-9 homolog (C. elegans), LIN9 |
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runt-related transcription factor 2, RUNX2 |
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HIF-1alpha |
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cooperates with Mitf |
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H4K20 tri-methylating enzymes Suv4-20h1 and Suv4-20h2 |
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Retinoblastoma-binding protein 2-homolog 1, RBBP2H1 |
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viral and cellular LxCxE-motif proteins |
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tripartite motif containing 27, TRIM27 |
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retinol binding protein 2, RBP2 |
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phosphatidylinositol-4-phosphate 5-kinases and diacylglycerol kinase zeta, DGKzeta |
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tumor suppressor P205 |
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protein arginine methyltransferase 2, PRMT2 |
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high mobility group AT-hook 2, HMGA2 |
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histone deacetylase 1, HDAC1 and pyrophosphatase (inorganic) 1, PP1 |
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anaphase-promoting complex/cyclosome, APC/C |
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interaction between ZBTB16 and RB1 is mediated through the RB1 pocket and the region of ZBTB16 that lies between its transcriptional repression (poxvirus and zinc-finger, POZ) and DNA-binding (zinc-finger) domains |
|
Aurora B, AURKB |
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E2F4 and RB1 play independent cell-intrinsic roles in fetal erythropoiesis |
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CDK5R1 |
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acts as a negative regulator of ZNF350 transcription |
|
KDM6A |
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catalytic subunit of protein phosphatase 1, PPP1CA |
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E2F1 which is dependent on the phosphorylation status of RB1 |
|
coordinates with E2F1 to regulate the ZNF350 promoter through the E2F motif |
|
target for lysine methylation by SETD7 |
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methylated at lysine 860 by SMYD2 (this modification permits direct binding of RB1 to the lysine methyl-binding protein L3MBTL, which may alter the function of RB1 in cells) |
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RBP1 binds to the pocket region of RB1 via an LXCXE motif and to the SAP30 subunit of the mSin3·HDAC complex |
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associates with and stabilizes pancreatic duodenal homeobox-1 (PDX1) that is essential for embryonic pancreas development and adult beta-cell function |
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interacting with RBP2 (RBP2 inhibits senescence and differentiation in RB1-defective tumor cells, and loss of RBP2 inhibits formation of RB1-defective endocrine tumors, suggesting that RBP2 also acts downstream of RB1) |
|
RB1 protein selectively represses specific E2F1 target genes via a TAAC element in senescent cells |
|
cooperative effect between CIC and RB1 in promoting G1 arrest is mediated, at least in part, by limiting CCNE expression |
|
SMAD2 overexpression inhibits the proliferation of junctional epithelium (JE) cells by down-regulating MYC and up-regulating CDKN2B and CDKN1B, which resulted in an increase in RB1, leading to cell-cycle arrest |
|
lysine methylation-dependent binding of TP53BP1 to the RB1 tumor suppressor |
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RB1 maintains quiescence and prevents premature senescence through upregulation of DNMT1 in mesenchymal stromal cells |
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role of KDM6B as a novel inducer of senescence-associated heterochromatin foci (SAHF), formation through demethylating RB1 |
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RB1 selectively inhibits innate IFNB1 production by enhancing deacetylation of IFNB1 promoter, exhibiting a previous unknown non-classical role in innate immunity, which also suggests a role of RB1 in the regulation of type I IFN production in inflammatory or autoimmune diseases |
|
SUMO1 conjugation of RB1 and LMNA is modulated by the SUMO protease SENP1 and sumoylation of both proteins is required for their interaction |
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MAZ is essential to bypass MYB promoter repression by RB1 family members and to induce MYB expression |
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