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Symbol TEAD4 contributors: mct/npt/pgu - updated : 22-12-2016
HGNC name TEA domain family member 4
HGNC id 11717
  • an N-terminal DNA-binding TEA (TEF-1, TEC1, and AbaA) domain
  • M-CAT binding domain
  • a C-terminal YAP-binding domain (YBD)
    interspecies homolog to murine Tead4
  • TEA domain family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
  • lack of nuclear localization of TEAD4 impairs the trophectoderm (TE)-specific transcriptional program in inner blastomeres, thereby allowing their maturation toward the inner cell mass (ICM) lineage
  • basic FUNCTION
  • may be important for both mitogen-stimulated fibroblast proliferation and skeletal muscle cell differentiation
  • acting as a transcriptional stimulator of VEGF by regulating VEGF promoter activity through binding to Sp1 site and may play an important role in the regulation of VEGF under hypoxia
  • playing a role in the control of the transcription of the VEGF gene, in ocular vascular endothelial cells
  • playing essential roles in mediating biological functions of YAP1
  • required for RCAN-1L expression through binding to the M-CAT site in its promoter
  • required for trophectoderm development
  • early transcription factor required for specification and development of the trophectoderm lineage, which includes expression of CDX2
  • may also function to promote angiogenic response
  • plays an important role in transcriptional regulation of angiogenic genes in hypoxic endothelial cells, and key regulator of angiogenesis in response to hypoxia
  • mammalian Tead proteins regulate cell proliferation and contact inhibition as a transcriptional mediator of Hippo signaling
  • play an important role in both endothelial cells and cardiomyocytes
  • TEAD4-driven increase of VEGFB plays an important role in communication between the endothelium and myocardium
  • plays an important role in endothelial cell function by regulating angiogenesis
  • stimulates promoter activity through an insulin response element and also mediates the effects of insulin on gene expression
  • is not required for specification of the trophectoderm lineage
  • plays a crucial role in maintaining energy homeostasis during preimplantation development
  • CELLULAR PROCESS nucleotide, transcription, regulation
    signaling signal transduction
    a component
  • component in the Hippo pathway
  • TEAD4–YAP1 complex showing that YAP1 binds to TEAD4 through three distinct regions of its N-terminal domain
  • TEAD4-VGLL4-CTBP2 ternary complex dynamically existed at the early stage of adipogenesis
    small molecule
  • interacting with VEGF (promoter GC-rich region containing four Sp1 response elements, located between -114 and -50,
  • essential for TEAD4 function)
  • activate NR5A1 gene expression
  • interacting with RCAN1 (RCAN1 may act as a proangiogenic factor, and therefore TEAD4 may also function to promote angiogenic response)
  • regulates the expression of HIF-1
  • acting at the promoter of the HIF1A gene to stimulate gene expression, and in turn increases the expression of downstream genes involved in angiogenesis
  • interacts with YAP1 mainly through the two short helices
  • interact with YAP1 (which lacks a DNA-binding domain but contains an activation domain) to form functional heterodimeric transcription factors that activate proliferative and prosurvival gene expression programs
  • in endothelial cells upregulates VEGFB, which is able to stimulate hypertrophic genes in cardiomyocytes
  • TEAD4-stimulated IGFBP1 expression may be central to the mechanism by which TEAD4 attenuates blood glucose levels (
  • S1PR1 is a potential target gene of TEAD4 and is involved in TEAD4-induced angiogenesis in endothelial cells
  • VGLL1-derived peptides bind to TEAD4 with nanomolar affinity
  • VGLL4 acted as an adaptor protein that enhanced the interaction between TEAD4 and CTBP2
  • cell & other
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in hypoxic endothelial cells, increasing VEGF promoter activity and VEGF expression
    Variant & Polymorphism
    Candidate gene
    Therapy target
    Tead4-/- embryos died at pre-implantation stages without forming the blastocoel