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FLASH GENE
Symbol WNT11 contributors: mct - updated : 29-08-2016
HGNC name wingless-type MMTV integration site family, member 11
HGNC id 12776
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cysteine rich, with a zinc finger-like motif
  • five glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila wingless (Wg) segment polarity gene
    Homologene
    FAMILY
  • WNT family
  • frizzled gene subfamily
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • ligand for the members of the frizzled members of receptors,modulating cell fate and cell behavior during vertebrate development
  • not required for cardiac differentiation, but functioning in regulation of cardiac morphogenesis
  • may be playing an important role in carcinogenesis through activation of the WNT signaling pathway
  • may be a key regulator of cardiac muscle cell proliferation and differentiation during heart development
  • has an essential role in the oriented elongation of the myocytes
  • required to control myocyte orientation and the action of the neural tube on the polarized elongation of myocytes is mediated, at least in part, by WNT11
  • involved in coordination of key signaling pathways
  • promotes osteoblast maturation and mineralization, through RSPO2
  • regulates the integration of intracellular and extracellular Ca2+, while also tuning dynamic relationships between subcellular Ca2+ domains, and refinement of electrical coupling by Wnt signals may be an important factor not only in cardiogenesis, but also in the establishment and maintenance of other epithelia in development
  • promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals
  • WNT5A and WNT11 are essential regulators of the response of second heart field progenitors to WNT/CTNNB1 signaling and they act by restraining WNT/CTNNB1 signaling during cardiac development
  • plays a crucial role in regulating MSC chondrogenic differentiation
  • WNT5A and WNT11 regulate epithelial-mesenchymal transition (EMT) by inducing p38 (MAPK14) phosphorylation
  • plays an important role in human mesenchymal stem cells (hMSCs) for enhancing the osteogenesis in an infectious environment
  • CELLULAR PROCESS cell organization/biogenesis
    cell communication
    PHYSIOLOGICAL PROCESS development
    text skeleton, kidney, lung, heart
    PATHWAY
    metabolism
    signaling signal transduction
    WNT signaling pahway, JNK/AP-1 and NF-kappaB signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • a direct target of ERG (potent ERG induction promoted morphological transformation through WNT11 signals
  • WNT-11/FZD7 controls cell adhesion by forming separate adhesion-modulating complexes (AMCs) with the paraxial protocadherin PCDH8 and C-cadherin via distinct FZD7 interaction domains
  • WLS has different roles in the polarized secretion of WNT11 and WNT3A and glycosylation processing of Wnts decides their secretory routes
  • stimulates proliferation, migration and invasion of cancer-derived cells, and increases activity of matrix metalloproteinase (MMP2 and MMP9)
  • significant correlation between WNT5B and WNT11 overall staining and presence of calcification, lipid score, fibrosis, and microvessels, in aortic valve calcification
  • cell & other
    REGULATION
    induced by hypoxia
    Other transcription of WNT11 is regulated primarily by HIF1A
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal and gastric cancer
    Susceptibility to high bone mass syndrome
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    as a possible target for cancer therapies, especially for tumors treated with antiangiogenic therapy
    ANIMAL & CELL MODELS
    WNT11 is required for heart formation in Xenopus embryos. This function is conserved in higher vertebrates (mice). The effect is mediated by non-cammical Wnt signaling which involves protein kinase C and Jun amino-terminal kinase