basic FUNCTION
| may be blocking cell cycle progression by down regulating thymidylate synthase expression |
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may modulate the internalization of beta-amyloid precursor protein |
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mediating APP trafficking and signalling by interaction |
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adaptor protein that binds to and forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain |
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functions as a "scaffold" protein to recruit various binding partners together to form a functional complex |
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functions in brain development and amyloid precursor protein (APP) signaling through its interaction with the mammalian enabled (ENAH) protein and APP, respectively |
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having role in nuclear signaling |
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APBB1, APBB2, APBB3 contribute to physiological APP processing and accumulation of APP metabolic products resulting from NMDAR activation |
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attenuates NOTCH1 signaling via the accelerated degradation of the membrane-tethered NOTCH1 in the cytoplasm |
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carries out different functions depending on its location in the regulation of NOTCH1 signaling |
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neuronal adaptor protein that mediates the assembly of multimolecular complexes through a variety of protein-protein interaction domains |
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adaptor protein that binds to the amyloid precursor protein (APP) |
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is a novel regulator of neurite outgrowth via controlling ARF6-RAC1 signaling |