Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GRB7 contributors: mct - updated : 24-09-2013
HGNC name growth factor receptor-bound protein 7
HGNC id 4567
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal proline-rich region,
  • a Ras-GTPase binding domain,
  • a PH domain, mediating GRB7 binding to phospholipids
  • an SH2 domain and a BPS domain in between the PH and SH2 domains , and SH2 can directly bind to the autophosphorylated PDGF beta-receptor
  • HOMOLOGY
    interspecies homolog to C.elegans newly identified gene
    Homologene
    FAMILY
  • GRB7/10/14 family
  • CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • mediating the coupling of multiple cell surface receptors to downstream signaling pathways in the regulation of various cellular functions
  • has potential importance in the progression of cancer
  • implicated as a downstream mediator of integrin-PTK2 signal pathways in the regulation of cell migration
  • implicated in PDGF signaling pathways in certain cell types by binding to the receptor directly or indirectly via SHC1
  • plays an important role in hepatocellular carcinoma progression and is strongly associated with expression of FAK
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interaction with both LY6G6F and GRB2 is mediated through its Src homology 2 domains and is dependent on the phosphorylation of LY6G6F
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    plays pivotal roles in activating signal transduction and promoting tumor growth in breast cancer cells with chromosome 17q11-21 amplification
    tumoral     --over  
    in invasive esophageal carcinomas
    tumoral   amplification    
    with ERBB2 in primary gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    GRB7 peptide inhibitor appears to be a promising molecularly targeted therapeutic agent against metastatic pancreatic cancer
    cancer  
    has potential to be developed as a therapeutic agent alone, in combination with traditional chemotherapy, or in combination with other targeting molecules, in several cancer
    ANIMAL & CELL MODELS