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FLASH GENE
Symbol WNT2B contributors: mct - updated : 04-09-2018
HGNC name wingless-type MMTV integration site family, member 2B
HGNC id 12781
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal hydrophibic domain
  • a WNT core domain with 24 cysteine residues
  • two N-glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila wingless (wg) segment polarity gene
    Homologene
    FAMILY WNT family
    CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION extracellular
    text
  • in the presence of ACSL5, WNT2B was unable to translocate into the nucleus and was enriched in mitochondria, which was paralleled by a significant decrease in Wnt activity
  • basic FUNCTION
  • modulating cell fate and cell behavior during vertebrate development
  • implicated in eye ciliary body induction
  • role for the lens in maintenance of WNT2B expression
  • WNT2B primarily plays a supportive role in gastrulation and organogenesis, functioning redundantly with canonical Wnts, such as WNT2, in numerous tissues
  • is likely required to maintain normal intestinal stem cells (ISCs) numbers and/or activity in the duodenum
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is one of canonical WNTs transducing signals through Frizzled (FZD) and LRP5/LRP6 receptors to beta-catenin-TCF/LEF signaling cascade
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DIAR9
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in several breast cancer cell lines
    constitutional       gain of function
    abnormal upregulation in the levels of WNT2B and WNT7B in neural tube defects (NTDs)
    tumoral     --over  
    of GLI1 and WNT2B might play a pivotal role during tumorigenesis of pancreatic cancer, and the high expression of WNT2B might be associated with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking Wnt2b were viable, fertile, and displayed a normal life span, however, the olfactory bulb in adult Wnt2b mutant mice was significantly reduced in length