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FLASH GENE
Symbol FOSB contributors: mct/npt - updated : 01-02-2023
HGNC name FBJ murine osteosarcoma viral oncogene homolog B
HGNC id 3797
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • basic leucine zipper (bZIP) protein
  • a C terminal transactivation domain
  • HOMOLOGY
    interspecies homolog to murine FBJ osteosarcoma viral (v-fos) oncogene B
    Homologene
    FAMILY
  • bZIP family
  • Fos subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • putative gene regulator for cellular mechanisms mediating neuronal excitability and survival
  • control of sensitivity to cockayne enhanced by delta FosB through changes in CDK5 level
  • implicated in the regulation of genes important for inflammation, proliferation, and differentiation and have been shown to be involved in wound healing (Neub 2007)
  • FOSB is a key regulator of FUS-mutant axon branching
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, antiapoptosis
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS behavioral , development , nervous system
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • forming heterodimers (the AP-1 complex) with JUN family of proteins
  • INTERACTION
    DNA binding
    RNA
    small molecule
  • cockayne
  • protein
  • CDK5
  • is the mediator of SERPINB2 transactivator function explaining the orientation dependence observed for SERPINB2 transactivator activity
  • FOSB and JUN can derepress transcription from the SERPINB2 promoter which may have general significance for SERPINB2-expressing cells
  • N4BP1 controls the proper function of keratinocytes and neutrophils by negatively regulating JUNB, FOSB, and CXCL1, respectively, and that is critical for psoriasis prevention
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Forebrain patterns of Fos and FosB induction during cancer-associated anorexia-cachexia in rat (Konsman 2005)