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FLASH GENE
Symbol LTB4R contributors: mct/npt - updated : 19-03-2010
HGNC name leukotriene B4 receptor
HGNC id 6713
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in the regulation of the inflammatory system
  • predominantly responding to ATP, involved in the regulation of cardiac muscle contraction
  • major neutrophil chemotactic factor released from the intraluminal thrombus of abdominal aortic aneurysms (Houard 2009)
  • G-protein-coupled receptors for leukotriene B4 functioning in host defense, inflammation, and immunity (Kuniyeda 2007)
  • in granulocytes transducing intracellular signals through the Gi- and G16-classes of G proteins, which inhibit cAMP production and raise the intracellular calcium concentration (Hikiji 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand LTB4 (LTB4 is produced in osteoclasts and activates LTB4R in an autocrine/paracrine manner) (Hikiji 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • inhibition of LTB4R functions may represent a strategy for preventing bone resorption diseases (potential therapeutic target for bone resorption diseases) (Hikiji 2009)
  • ANIMAL & CELL MODELS
  • osteoclasts from Blt1-deficient mice showed reduced calcium resorption activities compared with wild-type osteoclasts (Hikiji 2009)