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FLASH GENE
Symbol PDE3A contributors: mct/npt - updated : 10-09-2009
HGNC name phosphodiesterase 3A, cGMP-inhibited
HGNC id 8778
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • large hydrophobic domain at the N terminus
  • six transmembrane helices C terminal catalytic domain
  • HOMOLOGY
    interspecies homolog to murine Pde3a
    intraspecies homolog to cGMP inhibited nucleotide phosphodiesterase 3A
    Homologene
    FAMILY
  • cyclic nucleotide phosphodiesterase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • hydrolyzing both cyclic AMP (cAMP) and cyclic GMP (cGMP)
  • regulate cAMP levels in platelets, through protein kinase C-mediated phosphorylation and activation of PDE3A (Hunter 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by cAMP,cGMP
    Other activation/phosphorylation via Akt signaling pathway participates in regulating cAMP during thrombin activation of platelets (Zhang 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in failing hearts may play a causative role in the progression of heart failure, in part, by inducing CREM and promoting cardiac myocyte dysfunction (Yan 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS