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FLASH GENE
Symbol OAS1 contributors: mct - updated : 11-04-2018
HGNC name 2',5'-oligoadenylate synthetase 1, 40/46kDa
HGNC id 8086
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , tetramer
HOMOLOGY
Homologene
FAMILY
  • oligoademylate synthase family
  • 2-5A synthetase family essential for innate immune response against viral infection
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • mediating resistance to virus infection, control of cell growth, differentiation and apoptosis
  • plays a central role in the cellular innate antiviral response
  • is one of the major interferon-inducible proteins and a critical component of the host defense system against viral infection
  • potential role of OAS1 polymorphisms in respiratory infection
  • recognizes double-stranded RNA (dsRNA) using a previously uncharacterized protein/RNA interface that forms via a conformational change induced by binding of dsRNA
  • CELLULAR PROCESS cell life, differentiation
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    nucleotide
    a component components of the innate immune response to viruses
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by interferon induced
    ASSOCIATED DISORDERS
    corresponding disease(s) PAPHG
    Susceptibility
  • host susceptibility to viral infection
  • to multiple sclerosis (MS)
  • to prostate cancer
  • to Sjögren's syndrome (SS)
  • Variant & Polymorphism SNP , other
  • influencing host susceptibility to viral infection
  • association between rs10774671 and MS
  • significant association was observed between the rs2660 genotype (A/G) and prostate cancer
  • is a risk locus for SS and support a potential role for defective viral clearance due to altered IFN response as a genetic pathophysiological basis of this complex autoimmune disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS