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FLASH GENE
Symbol RAB4A contributors: mct/npt/pgu - updated : 27-01-2017
HGNC name RAB4A, member RAS oncogene family
HGNC id 9781
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP , PhosphoP
HOMOLOGY
interspecies homolog to murine Rab4a
homolog to yeast S.cerevisiae Ypt1 and sec4
Homologene
FAMILY
  • small GTPase superfamily
  • Rab family
  • CATEGORY protooncogene , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • is localized to early and recycling endosomes and is required for the rapid recycling of receptors from early endosomes to the cell surface
  • membrane-associated and cytoplasmic when phophorylated by CDC2 kinase during mitosis
  • basic FUNCTION
  • GTPase
  • regulating vesicular transport pathways
  • regulating intracellular transport
  • may be involved in vesicular trafficking
  • playing a role n recylcing from early endosomes to the plasma membrane
  • via its interaction with RUFY1, regulate integrin trafficking and are involved in the migration of NIH 3T3 fibroblasts
  • participates in adherens junction dynamics in tetis
  • play an essential role in the control of the glucose transporterSLC2A4 trafficking, which is essential for insulin-mediated glucose uptake
  • regulating a recycling pathway that is a critical effector of FLT1 during branching morphogenesis of the vasculature
  • RAB14 and RAB4 regulate endosomal functions through cooperative interactions with their dual effector, RUFY1
  • RAB4A and RAB5A GTPases are key players in the regulation of endocytosis
  • is a master regulator of receptor recycling from endocytic compartments to the plasma membrane
  • mitochondrial turnover involves endosomal traffic regulated by RAB4A, a small GTPase that is overexpressed in lupus T cells
  • RAB4A is involved in the regulation of endocytosis and protein trafficking in cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text vesicle transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP binding
  • protein
  • interacting with RUFY1, a RAB4A effector involved in early endosomal traffic
  • down- or up-regulation of RAB4A expression or RAB4A function triggered inhibition or increase of CTSL secretion respectively
  • evolutionarily conserved function of PTPN23-RAB4A in the regulation of endocytic trafficking, cell adhesion and migration
  • TBC1D16 interferes with RAB4A-mediated EGFR recycling, thereby promoting its degradation
  • RAB4A decreases the KCNH2 density at the plasma membrane by increasing the endogenous NEDD4L expression
  • ARL1 links RAB4A-dependent formation of endosomal sorting domains with downstream assembly of adaptor protein complexes that constitute the endosomal sorting machinery
  • RABEP1 is recruited by both RABGEF1 recognizing ubiquitylated cargo and by RAB4A to activate RAB5A in a feed-forward manner
  • cell & other
    REGULATION
    inhibited by phopshorylation by CDC2 kinase during mitosis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    laminar shear stress upregulated RAB4A expression, which contributed to improved EC autophagy and function
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS