SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,cytosolic,vesicle
|
text
| is localized to early and recycling endosomes and is required for the rapid recycling of receptors from early endosomes to the cell surface |
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membrane-associated and cytoplasmic when phophorylated by CDC2 kinase during mitosis |
basic FUNCTION
| GTPase |
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regulating vesicular transport pathways |
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regulating intracellular transport |
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may be involved in vesicular trafficking |
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playing a role n recylcing from early endosomes to the plasma membrane |
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via its interaction with RUFY1, regulate integrin trafficking and are involved in the migration of NIH 3T3 fibroblasts |
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participates in adherens junction dynamics in tetis |
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play an essential role in the control of the glucose transporterSLC2A4 trafficking, which is essential for insulin-mediated glucose uptake |
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regulating a recycling pathway that is a critical effector of FLT1 during branching morphogenesis of the vasculature |
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RAB14 and RAB4 regulate endosomal functions through cooperative interactions with their dual effector, RUFY1 |
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RAB4A and RAB5A GTPases are key players in the regulation of endocytosis |
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is a master regulator of receptor recycling from endocytic compartments to the plasma membrane |
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mitochondrial turnover involves endosomal traffic regulated by RAB4A, a small GTPase that is overexpressed in lupus T cells |
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RAB4A is involved in the regulation of endocytosis and protein trafficking in cells |