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FLASH GENE
Symbol LAMP1 contributors: mct/npt/pgu - updated : 07-06-2015
HGNC name lysosomal-associated membrane protein 1
HGNC id 6499
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • two extracellular N glycosylation sites
  • a transmembrane (1TM) segment
  • a short cytoplasmic tail
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Lamp1
    Homologene
    FAMILY
  • LAMP family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • presenting carbohydrate ligands to selectins
  • could be involved in keratinocyte differentiation, but apparently not through interaction with galectin-3
  • LAMP1 and LAMP2 are delivered to phagosomes during the maturation process
  • can serve as a cell surface binding site for amelogenin on dental follicle cells and cementoblasts
  • LAMP1 and LAMP2 have distinct functions, and the presence of both proteins together is required for the essential regulation of autophagy to avoid embryonic lethality
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • major constituents of lysosomal membranes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with AMELX (AMELX interacts with the transmembrane proteins CD63 and LAMP (lysosome-associated membrane protein) 1, which are involved in endocytosis)
  • specific receptor for ERAP2, it is not a receptor for M180 amelogenin
  • MCOLN1 loss specifically causes, an increase in the lysosomal protease CTSB and the lysosomal membrane protein LAMP1
  • cell & other i5 lysosomal associated
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Gaucher disease with severe clinical manisfestations
    constitutional     --other  
    differentially expressed in acute and chronic human thymic involution
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • LAMP1 expression may be a sensitive marker for the cytotoxic activity determination
  • Therapy target
    ANIMAL & CELL MODELS