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FLASH GENE
Symbol RAP2A contributors: mct - updated : 06-11-2014
HGNC name RAP2A, member of RAS oncogene family
HGNC id 9861
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Rap2a
Homologene
FAMILY Ras family of small GTP-binding proteins
CATEGORY signaling
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,endosome
intracellular,cytoplasm,cytosolic
text
  • localizing and recruiting TNIK to the recycling endosomes in a palmitoylation-dependent manner (Uechi, 2009)
  • basic FUNCTION
  • involved in small GTPase mediated signal transduction
  • playing a possible role in membrane shedding
  • functioning as a slowly responding molecular switch in the RAP1A signaling cascade
  • is a molecular link that couples the formation of microvilli in intestinal cell directly to the preceding cell polarization
  • endothelial barrier resistance is determined by the combined antagonistic actions of RAP1A and RAP2A
  • acts via TNIK to regulate the stability of LRP6 receptor for WNT/CTNNB signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • NEDD4/RAP2A/TNIK signaling pathway regulates neurite growth and arborization in mammalian neurons
  • a component
  • NEDD4, the serine/threonine kinase TNIK, and RAP2A form a complex that controls NEDD4-mediated ubiquitination of RAP2A
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ARHGAP29, putative specific effector of RAP2A to regulate RHO
  • MAP4K4 is a putative effector of RAP2A mediating the activation of JNK by RAP2A
  • by binding to phosphatidic acid enriched at the apical membrane, RAPGEF2 locally activates RAP2A resulting in induction of brush border formation via a pathway that includes the polarity players TNIK, STK26 and Ezrin
  • RAP2C is spatially segregated from RAP2A signaling as it is not enriched at the apical membrane after polarization
  • cell & other
    REGULATION
    activated by guanine nucleotide-exchange factors (GEF) EPAC,
    and EPAC2 in a cAMP-dependent manner, and GFR
    Other requires palmitoylation for membrane association and TNIK activation (Uechi, 2009)
    requires palmitoylation for induction of TNIK-mediated phenotype, the suppression of cell spreading (Uechi, 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in sporadic breast cancer, grade I
    constitutional     --low  
    age-downregulated in frontal cortex
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS