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FLASH GENE
Symbol SRGN contributors: mct - updated : 20-08-2011
HGNC name serglycin
HGNC id 9361
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 18 AA glycosaminoglycan-attachment region
  • HOMOLOGY
    Homologene
    FAMILY
  • serglycin family
  • CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,granule
    text core of secretory granule
    basic FUNCTION
  • may be acting as a mediator of granule-mediated apoptosis
  • hematopoietic cell granule proteoglycan, which may be important for neutralizing hydrolytic enzymes
  • may be involved in the retention of the proteases after their entry into secretory vesicles
  • important role in secretory processes in human monocytes
  • hematopoietic cell secretory granule proteoglycan, crucial for storage of specific secretory proteins in mast cells, neutrophils, and cytotoxic T lymphocytes
  • serglycin proteoglycan is a novel player in mast cell apoptosis
  • major proteoglycan in human endothelial cells, mainly secreted to the apical medium and implicated in chemokine secretion
  • potential role for serglycin in regulating proinflammatory activities of endothelial cells, possibly by affecting the storage and/or secretion of chemokines
  • adipocytokine highly expressed in epicardial adipose tissue (EAT)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by EBV
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in highly metastatic cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serves as an independent prognostic indicator of metastasis-free survival and disease-free survival in nasopharyngeal carcinoma patients
  • Therapy target
    ANIMAL & CELL MODELS
  • SG-/- murine platelet function deficiencies are related to inadequate packaging and secretion of selected alpha-granule proteins and reduced secretion of dense granule contents critical for platelet activation (