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FLASH GENE
Symbol PCCA contributors: npt/ - updated : 10-07-2006
HGNC name propionyl Coenzyme A carboxylase, alpha polypeptide
HGNC id 8653
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C-terminal biotin-binding domain
  • a biotin carboxylase domain, defined by homology with other biotin-dependent carboxylases
  • an ATP-GRASP domain
  • mono polymer heteromer , heptamer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • propionyl-CoA carboxylase, alpha polypeptide, biotin-dependent
  • mitochondrial conversion of propionyl CoA to methylmalonyl CoA, branched chain
  • involved in valine, isoleucine catabolism,energy pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits
  • INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • biotin
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PCCA
    related resource Propionyl CoA Carboxylase Page
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS