basic FUNCTION
| playing an important role in innate immunity |
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involved in host defense and inflammatory processes of the lung |
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also involved in the surface tension lowering ability of pulmonary surfactant |
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plays an important role in the lung during bacterial infection regulating protease and antiprotease activity |
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stimulates the release of neutrophil chemotactic factor by alveolar type II cells, and this effect is mediated by the receptor for SFTPA1 specifically expressed by these cells |
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most abundant pulmonary soluble collectin, that modulates innate and adaptive immunity of the lung, partially via its direct effects on alveolar macrophages (AM) |
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novel role for SFTPA1 in modulating endolysosomal trafficking via RAB7A in primary alveolar macrophages (AM) |
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SFTPA1, SFTPA2 plays a key role in innate lung host defense, in surfactant-related functions, and in parturition |
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plays critical roles in the innate immune system and surfactant homeostasis of the lung |
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SFTPA1 levels may be important to maintain surfactant function in the presence of high cholesterol within surfactant |
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fetal lungs produce signals to initiate labor when mature and NCOA1/NCOA2-dependent production of SFTPA1B and platelet-activating factor (PAF) is crucial for this process |
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associated with host defense in the lung, and contributes to the pathogenesis of chronic obstructive pulmonary disease (COPD) |
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innate host defense molecules, surfactant protein A1 (SFTPA1), and SFTPA2 differentially affect the function and proteome of the alveolar macrophages |