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FLASH GENE
Symbol ACACA contributors: mct - updated : 07-06-2016
HGNC name acetyl-Coenzyme A carboxylase alpha
HGNC id 84
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
HOMOLOGY
Homologene
FAMILY
  • biotin containing enzyme family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • acetyl-CoA carboxylase alpha, biotin dependent
  • catalyzing the synthesis of malonyl-CoA, an intermediate substrate playing a pivotal role in the regulation of fatty acid metabolism and energy production
  • major regulatory enzyme of fatty acid biosynthesis
  • crucial roles in de novo fatty acid biosynthesis and lipogenesis and essential for cancer cell survival
  • involved in the biosynthesis of fatty acids, and malonyl-CoA produced is used as a building block to extend the chain length of fatty acids by fatty acid synthase (FAS)
  • with FABP2 are both key factors of lipogenesis and transport
  • essential role for ACACA-mediated de novo lipogenesis as a regulator of CD8(+) T cell expansion
  • ACACA and ACLY regulate the levels of ETV4 under hypoxia via increased alpha-ketoglutarate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • biotin
  • protein
  • interacting with BRCT domain of BRCA1, and affecting lipogenesis
  • regulated at a tertiary level by MID1IP1, which facilitates ACACA polymerization and enhances enzymatic activity
  • PRKAA1 might regulate NADPH homeostasis by inhibiting ACACA and ACACB
  • PRKAA1-mediated inhibition of ACACA is required to maintain the NADPH and reactive oxygen species levels after matrix detachment
  • renin synthesis and secretion are regulated by PRKAA1 and coupled to metabolism by phosphorylation of ACACA
  • cell & other
    REGULATION
    activated by SREBF1 in lipogenesis (activating number of enzyme genes, such as FASN or ACACA, that are involved in this pathway at the transcriptional level
    Other phospho/dephosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s) ACACA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    with the decreased expression of PRKAB1 and overexpression of MLYCD are important regulators of the maturation of fatty acid oxidation in the newborn heart
    Susceptibility to breast cancer
    Variant & Polymorphism other ACACA polymorphism increasing breast cancer risk
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS