| basic FUNCTION
| playing a role in regulation of pre-mRNA splicing and in the stimulation of translation initiation |
|
promoting the binding of U2 snRNP to pre-mRNAs |
|
acting via the protein degradation ubiquitin-proteasome pathway |
|
repressing alpha-actinin SM exon splicing  |
|
post-transcriptional switch from PTBP1 to PTBP2 controls a widespread alternative splicing program during neuronal development |
|
controls the transition from exon definition to an intron defined spliceosome |
|
inducing human papillomavirus type 16 late gene expression by interfering with splicing inhibitory elements at the major late 5' splice site |
|
not oncogenic, can either promote or antagonize a malignant trait dependent upon the specific intra-cellular environment |
|
inhibits cytomegalovirus replication by interfering with major immediate-early (MIE) gene splicing through competition with U2AF for binding ot the polypyrimidine tract in MIE gene introns |
|
PTBP1 and HNRNPL are positive regulators of SLC7A1 mRNA translation via the internal ribosome entry site (IRES) under stress conditions that cause a global decrease of protein synthesis |
|
PTBP1 and an HNRNPL, promote the efficient translation of SLC7A1 mRNA during amino acid starvation |
|
influences negative strand RNA synthesis of dengue virus |
|
promoting pre-mRNA 3' end processing in collaboration with hnRNPH |
|
with HNRNPA2B1, and HNRNPA1, have critical role in promoting PKM2 production in tumours, and overexpression of some combination of them is, like PKM2 expression, likely to be a general phenomenon in cancer |
|
abundant RNA-binding protein binding to polypyrimidine tracts, such as those present at or upstream of 3prime splice sites, and that can regulate alternative splicing by creating a zone of silencing |
|
PTBP1, a splicing regulator, is replaced in the brain and differentiated neuronal cell lines by PTBP2 |
|
PTBP1 and its brainspecific homologue, PTBP2, are associated with pre-mRNAs and influence pre-mRNA processing, as well as mRNA metabolism and transport |
|
widely expressed RNA binding protein that acts as a regulator of alternative splicing and of cytoplasmic mRNA functions |
|
functions as a key regulator of alternative pre-mRNA splicing in the nucleoplasm and promotes internal ribosome entry site-mediated translation initiation of viral and cellular mRNAs in the cytoplasm |
|
PTBP1 and PTBP2, are also nonconserved cryptic exon repressors, and PTBP1 and PTBP2 are members of a family of cryptic exon repressors |
|
PTBP1 and PTBP2 reprogram developmental pre-mRNA splicing in neurons |
|
PTBP1 and PTBP2 serve both specific and redundant functions in neuronal pre-mRNA splicing |
|
regulates alternative splicing of many target genes involving in tumorgenesis in colon cancer cells |
|
PTBP1 was required for proper expression of the MYC-dependent gene program induced in germinal centers (GCs) B cells receiving T cell help and directly regulated the alternative splicing |
|
contributes likely to spermatogenesis through regulation of spermatogonia proliferation |
|
is essential for the humoral immune response |
|
PTBP1 induces bladder cancer Lymph node metastasis and proliferation through an alternative splicing mechanism |
|
translational regulation of PTBP1 protein levels during the cell cycle, which may affect downstream regulation of alternative splicing and translation mediated by PTBP1 protein isoforms |
|
PTBP1 controls mRNA abundance and alternative splicing of important cell cycle regulators including CCND2, MYC, RBL1 and CDC25B |
|
PTBP1, PTBP2 are essential for B cell development |
