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FLASH GENE
Symbol GNG5 contributors: mct - updated : 08-12-2021
HGNC name guanine nucleotide binding protein (G protein), gamma 5
HGNC id 4408
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP
mono polymer heteromer , trimer
HOMOLOGY
interspecies ortholog to murine Gng5
homolog to Xenopus Xl.7680
homolog to zebrafish Dr.9659
homolog to C.elegans K02A4.2
Homologene
FAMILY G protein gamma family
CATEGORY receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • modulating or transducing various transmembrane signaling systems
  • required for the GTPase activity and for the replacement of GDP by GTP
  • PPP1R1A, OTULINL, ENO2, and GNG5 are potential regulators of islet function
  • likely a critical role of GNG5 in cortical development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component heterotrimeric G-protein GTPase, gamma-subunit
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GDP, GTP
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gliomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is an independent prognostic indicator for glioma patients, as well as a promising subtype-associated biomarker in molecular classification of gliomas.
  • Therapy target
    ANIMAL & CELL MODELS