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Symbol SERPINB5 contributors: mct/pgu - updated : 30-04-2010
HGNC name serpin peptidase inhibitor, clade B (ovalbumin), member 5
HGNC id 8949
  • serine protease inhibitor domain
  • secondary structure
  • G alpha-helix (G-helix), an internal salt bridge or the P1 position of the reactive center loop, involved in the previously reported interactions of maspin with ITGB1
  • conjugated GlycoP
    mono polymer monomer
    interspecies homolog to murine Serpinb5 (89.1pc)
    homolog to rattus Serpinb5 (88.0pc)
  • serpin family
  • Ov-serpin subfamily
  • CATEGORY enzyme , regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
  • nucleocytoplasmic distribution in breast and prostate cells
  • intracellular nucleocytoplasmic protein that cannot be secreted
  • basic FUNCTION
  • inhibitor of prostate tumor progression, preventing the local invasiveness
  • inhibiting tumor growth and tumor angiogenesis, reducing osteolysis
  • playing an important role in the premalignancy of the prostate gland
  • may contribute to bladder cancer development and DNA methylation and histone deacetylation may be important for regulating maspin gene activation in bladder cancer cells
  • having a potential role for tumour metastasis in gastric cancer
  • modulating cell death and invasion in cervical cancer cells
  • might function with the cornea to regulate cell adhesion to extracellular matrix
  • blocking the growth, invasion and metastatic properties of mammary tumors
  • tumor inhibitor properties may be linked to its nuclear localization
  • suppressing the invasive ability of pancreatic ductal adenocarcinoma cells
  • plays a role in reducing the prostate tumor cell's ability to seed to bone
  • stimulates apoptosis, inhibits motility, invasion and cancer metastasis
  • may be restricted to an intracellular, possibly nuclear, role in which it influences cell-matrix interactions indirectly and is probably released only as a consequence of cell damage or necrosis
  • potentially exerts its role in the nucleus at the level of gene or chromatin regulation and thus indirectly affects the cell-matrix interaction or differentiation state
  • potent angiogenesis inhibitor and one of the key molecules that play a key role in endothelial cell (EC) cell adhesion and migration
  • affects cell adhesion and cytoskeleton reorganization through an integrin signal transduction pathway
  • decreases cell migration, invasion, proliferation, and angiogenesis, while increasing apoptosis and adhesion (
  • CELLULAR PROCESS cell communication
    a component
    small molecule
  • interacting with PRSS21
  • interacts with the transcription factor IRF6
  • regulates the activation of ILK and PTK2 and causes the reorganization of the actin cytoskeleton
  • inhibits cell migration by inhibiting RAC1 and CDC42
  • physically associates with both PLAUR and ITGB1, thus producing a complex that regulates both cell motility and adhesion
  • cell & other
    activated by TP53
    induced by PTEN and TP53 under hypoxic conditions in gliblastoma cells
    inhibited by PRSS21 (maybe)
    nuclear IKK-alpha activation, thereby promoting the metastatic phenotype in prostate cancer
    Other up-regulated in ovarian epithelial cells by BRCA1 185DelAG mutant protein
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    frequently in advanced cancer with metastases
    tumoral     --over  
    in high-grade prostate intraepithelial neoplasia (HGPIN)
    tumoral     --low  
    by hypermethylation in papillary thyroid carcinomas
    tumoral     --over  
    in lung cancer (squamous cell carcinomas) and in preneoplastic bronchial lesions
    tumoral     --over  
    by hypomethylation in a large fraction of pancreatic cancer cell lines and primary pancreatic carcinomas
    Variant & Polymorphism
    Candidate gene
  • increased expression of SERPINB5 is associated with metastasis of hepatocellular carcinoma
  • detection of SERPINB5 in blood may indicate aggressive disease in breast cancer
  • Marker
  • may be a useful marker to identify the potential for progression in oral squamous cell carcinoma
  • cytoplasmic mSERPINB5 may play an important role in lung carcinomas by regulating apoptosis and thus is a favorable prognostic marker for adenocarcinoma patients whereas nuclear localization may be linked to promotion of angiogenesis
  • Therapy target