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FLASH GENE
Symbol ADORA3 contributors: npt/ - updated : 15-10-2007
HGNC name adenosine A3 receptor
HGNC id 268
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • conjugated GlycoP , LipoP
    HOMOLOGY
    interspecies ortholog to murine Adora3
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION
    text expressed weakly in the cytoplasm (Cui 2008)
    basic FUNCTION
  • adenosine receptor A3, activating adenylate cyclase
  • involved in signal amplification, controlling ATP gradient sensing and migration of neutrophils
  • protecting the ventricular heart cell against injury during a subsequent exposure to ischemia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in peripheral blood mononuclear cells of rheumatoid arthritis patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS