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FLASH GENE
Symbol G6PC contributors: mct/npt/pgu - updated : 01-04-2009
HGNC name glucose-6-phosphatase, catalytic subunit
HGNC id 4056
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • glucose-6-phosphatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • catalyses the final step in the gluconeogenic and glycogenolytic pathways, the hydrolysis of glucose-6-phosphate to glucose
  • involved in catalytic gluconeogenesis, energy pathway
  • may be a single membrane channel protein acting both as a hydrolase and a translocase
  • key enzyme in homeostatic regulation of blood glucose levels
  • possible role for PCK2 and G6PC in the DNA damage response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GSD1A
    Susceptibility sudden and unexpected death
    Variant & Polymorphism other promoter polymorphism, which lowers expression, potentially increasing risk of hypoglycaemia and hence risk of sudden and unexpected death
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS