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FLASH GENE
Symbol AKR1C4 contributors: mct - updated : 16-10-2018
HGNC name aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
HGNC id 387
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
Homologene
FAMILY aldoketo-reductase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • chlordecone reductase (3-alpha hydroxysteroid dehydrogenase, type I), catalyzing the detoxification of organochloride pesticids
  • AKR1C2, AKR1C4, are involved in the metabolism of steroids and other carbonyl compounds including drugs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism drug , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by long-chain fatty acids that inhibit AKR1C1, AKR1C2, AKR1C4
    ASSOCIATED DISORDERS
    corresponding disease(s) SRXY8
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    are responsible for sexual development dysgenesis
    Susceptibility to paranoid ideation during mania or hypomania in bipolar disorder
    Variant & Polymorphism SNP reduced the risk of exhibiting paranoia in bipolar disorder
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS