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FLASH GENE
Symbol RAD52 contributors: mct/ - updated : 27-03-2014
HGNC name RAD52 homolog (S. cerevisiae)
HGNC id 9824
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • self associating into seven-membered rings
  • two DNA binding sites (possible roles for the second DNA binding site in Rad52-mediated recombination reactions)
  • mono polymer heptamer
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae RAD52
    Homologene
    FAMILY
  • RAD52 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in meiotic recombination
  • plays essential roles in homology-dependent double-strand break repair
  • promoting the catalysis of DNA double strand break repair by the RAD51 recombinase
  • may be may exerting topological effects on the replication fork during replication repair
  • recombination mediator protein participates in maintenance of genomic integrity by functioning in homologous recombination (HR), homology-directed DNA repair (HDR), and rescue of collapsed replication forks
  • cooperates with OGG1 to repair oxidative DNA damage and enhances the cellular resistance to oxidative stress
  • role in the repair of oxidative DNA damage through a direct stimulation of the DNA glycosylase OGG1
  • with condensin, act antagonistically in the control of rDNA stability
  • dual role in controlling rDNA stability (under normal physiological conditions, it functions to maintain genomic stability through a controlled DSB repair mechanism outside the nucleolus but inappropriate localization to the nucleolus causes catastrophic events, such as cellular lifespan and reduced viability by stimulating extrachromosomal rDNA circle formation)
  • independent and alternative repair pathway of homologous recombination and a target for therapy in BRCA2-deficient cells
  • LIG4 and RAD52 genes play important roles in DNA repair mechanisms
  • CELLULAR PROCESS cell cycle,division,meiosis
    nucleotide, recombination
    nucleotide, repair, recombination
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with phosphorylated BRCA1, BRCA2 and RAD51 for ATP dependent DNA repair of double strand breaks through homologous recombination
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • colocalizing with RPA1 heterotrimeric ssDNA binding protein
  • interacting with OGG1 (interaction has reciprocal functional consequences as OGG1 inhibits RAD52 catalytic activities and RAD52 stimulates OGG1 incision activity, likely increasing its turnover rate)
  • stably binds and wraps both, protein free and RPA1-coated ssDNA
  • specifically inhibiting RAD51 inhibition pathway
  • interact physically with the WRN helicase
  • involved in cellular response to DNA damage including phosphorylation of RAD52 by ABL kinase at tyrosine 104
  • RAD52 is potentially an alternative repair pathway of RAD51-mediated homologous recombination (HR)
  • chromatin PTEN is involved in DNA damage response partly through regulating RAD52 sumoylation
  • RAD52/MUS81-dependent mechanism promoting cell viability and genome integrity in checkpoint-deficient cells, and disclose the involvement of MUS81 to multiple processes after replication stress
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS